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Water can penetrate the nail as can many other substances including paraquat, a fast acting herbicide that is harmful to humans, urea which is often an ingredient in creams and lotions meant for use on hands and fingers, and several fungicidal agents such as salicylic acid, miconazole branded Monistat, natamycin; and sodium hypochlorite which is the active ingredient in common household bleach (but usually only in 2–3% concentration). The fingernail bed is briefly depressed to turn the nail-bed white.

When the pressure is released, the normal pink colour should be restored within a second or two.

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It is not visible in some individuals while it is highly prominent on others.

Together, the eponychium and the cuticle form a protective seal.

The cuticle is the semi-circular layer of almost invisible dead skin cells that "ride out on" and cover the back of the visible nail plate while the eponychium is the fold of skin cells that produces the cuticle.

The lateral margin (margo lateralis) lies beneath the nail wall on the sides of the nail, and the nail groove or fold (sulcus matricis unguis) are the cutaneous slits into which the lateral margins are embedded. A healthy fingernail has the function of protecting the distal phalanx, the fingertip, and the surrounding soft tissues from injuries.

It also serves to enhance precise delicate movements of the distal digits through counter-pressure exerted on the pulp of the finger. Finally, the nail functions as a tool enabling, for instance, a so-called "extended precision grip" (e.g.

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