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Since 5-HT2C receptors have been implicated in the control of depression, OCD, and appetite, agonism at the 5-HT2C receptor might be associated with therapeutic potential in obsessive compulsive disorder, obesity, and depression.5-HT2C agonism has been demonstrated to induce anorexia via enhancement of serotonergic neurotransmission via activation of 5-HT2C receptors; it is conceivable that the 5-HT2C agonist actions of aripiprazole may, thus, be partly responsible for the minimal weight gain associated with this compound in clinical trials.Based on this profile, one can predict that aripiprazole may have antiobsessional and anorectic actions in humans.(maximum plasma concentration) is achieved 3–5 hours after oral dosing.The liquid form (oral solution) of this medication may contain up to 15 grams of sugar per dose.Antipsychotics like aripiprazole and stimulant medications, such as amphetamine, are traditionally thought to have opposing effects to their effects on dopamine receptors: stimulants are thought to increase dopamine in the synaptic cleft, whereas antipsychotics are thought to decrease dopamine.The authors concluded that for acute psychotic episodes aripiprazole results in benefits in some aspects of the condition.

Its only known active metabolite is dehydro-aripiprazole, which typically accumulates to approximately 40% of the aripiprazole concentration.Since the actions of aripiprazole differ markedly across receptor systems aripiprazole was sometimes an antagonist (eg at 5-HT6 and D2L), sometimes an inverse agonist (eg 5-HT2B), sometimes a partial agonist (eg D2L), and sometimes a full agonist (D3, D4).Aripiprazole was frequently found to be a partial agonist, with an intrinsic activity that could be low (D2L, 5-HT2A, 5-HT7), intermediate (5-HT1A), or high (D4, 5-HT2C).The 2016 NICE guidance for treating psychosis and schizophrenia in children and young people recommended aripiprazole as a second line treatment after risperidone for people between 15 and 17 who are having an acute exacerbation or recurrence of psychosis or schizophrenia.A 2014 NICE review of the depot formulation of the drug found that it might have a role in treatment as an alternative to other depot formulations of second generation antipyschotics for people who have trouble taking medication as directed or who prefer it.

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